FUS Instruments

Breaking Barriers: High Resolution Focused Ultrasound for Small Animal Research

New Publication Alert! Tissue-type Differences in Focused Ultrasound and Microbubble-mediated Drug Delivery to the Brain Exist at Vessel Level (Theranostics, 2026)
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FUS Instruments will be at the World Molecular Imaging Congress (WIMC) Conference in Salt Lake City, Utah, USA. See you there!
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New FUS Installation! RK-50 installed in XXX, June, 2026
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FUS Instruments will be attending the June 2026 ISTU Conference in Trondheim, Norway. See you there!
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New Publication Alert! Focused ultrasound expands intra-CSF AAV delivery to deep brain regions in rats and non-human primates (Molecular Therapy, 2026)

Research Grade Ultrasound Systems

High precision focused ultrasound enables scientists worldwide to explore novel drug delivery and drug development, as well as investigate new treatments for oncology, neurology, and cardiovascular diseases.

Focused Ultrasound Systems

Precision tools specifically engineered to allow researchers to deliver focused ultrasound in preclinical models.

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Specialized Customizable Transducers

Our team of experts is ready to help you configure the perfect FUS setup for your specific research goals.

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FUS-Specific Accessories

FUS application specific accessories to enable precise image-based anatomical targeting and improve acoustic delivery.

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Precision Engineering for Research Excellence

Our commitment to precision and innovation has made us the preferred partner for leading research institutions worldwide.

  • Precision Targeting: Achieve pinpoint accuracy in acoustic delivery with atlas-integrated software and advanced 3-axis positioning systems.
  • Scalable Solutions: We offer a clear pathway from benchtop pilot studies (RK-20/50) to high-resolution preclinical imaging (RK-300).
  • Seamless Integration: Our systems are designed to fit your existing workflow, from standard laboratory stereotactic frames to high-field small-bore and clinical MRI scanners.
  • Publishable Reliability: Work with hardware and software built specifically for the rigorous demands of the research environment, ensuring repeatable and peer-review-ready results for high-impact journals.

  • Expert-Led Support: Partner with specialized engineers who understand your science, providing the deep technical training and custom hardware tweaks needed to push your research boundaries.

Trusted Across Diverse Research Fields

Our ultrasound equipment supports groundbreaking research in multiple scientific disciplines.

BBB disruption

Reversibly permeabilize the BBB to deliver therapeutics with sub-millimeter precision.

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Neuromodulation

Target deep-brain structures to excite or inhibit neural activity without invasive implants.

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Sonodynamic Therapy

Activate sonosensitizers to trigger apoptosis in deep-seated tumors.

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Thermal Therapy

Command precise focal heat for rapid coagulative ablation or controlled drug release.

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Featured Publications

Discoveries made using FUS Instruments are shaping the future of clinical neurology. Explore the growing body of research powered by FUS Instruments, where our RK series platforms have enabled scientists worldwide to achieve consistent, localized, and safe blood-brain barrier disruption and neuromodulation in preclinical models.

Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations

Nature Biomedical Engineering (2025)

Researchers at the University of Virginia performed focused ultrasound-microbubble using the MRI-guided small bore FUS Instruments RK-300 to treat vascular lesions in the central nervous system of mice. The study showed that one month of FUS treatment is a minimally invasive modality to successfully control the growth of cerebral cavernous malformations (CCMs).

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Acoustically targeted measurement of transgene expression in the brain

Science Advances (2024)

Rice University researchers found an unconventional use for FUS-mediated BBB opening. The group introduced a novel non-invasive diagnostic protocol for the detection of brain neuronal markers using FUS (RK-50) treatment to induce release and recovery of these biomarkers in the bloodstream. This method is a spatially specific, repeatable and non-damaging alternative to existing biopsy-based methods.

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Repeated 5-aminolevulinic acid mediated sonodynamic therapy using magnetic resonance guided focused ultrasound in rat brain tumour models

Scientific Reports (2025)

An early prototype of MRI-guided FUS system RK-300 was used by researchers at the University of Toronto to demonstrate the successful use of sonodynamic therapy with sonosensitizing agents and transcranial FUS delivery in improving survival outcomes of rats with late-stage glioblastoma.

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MRI-guided focused ultrasound blood–brain barrier opening increases drug delivery and efficacy in a diffuse midline glioma mouse model

Neuro-Oncology Advances (2023)

In this study, RK-50 with modified MR compatible bed attachment was used for image-guided BBB opening to deliver drug to an orthotopic diffuse midline glioma tumor. The group at University of Colorado – Boulder described the safety and efficacy of repeated FUS treatments in improving survival outcomes for diffuse intrinsic pontine glioma mice.

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Precise antibody delivery to the brain via nanobubble-actuated focused ultrasound alleviates depression

Proc. Natl Acad. Sci. USA (2025)

A group at Shanghai Tech University described a protocol to deliver human monoclonal antibodies using repeated multitarget FUS to small brain regions like the habenula in mice. Their experiments showed an alleviation of depression-like symptoms for at least 2 weeks in a mouse model with FUS-NB (RK-50) mediated BBB opening to administer drugs.

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Focused ultrasound with barbiturate-loaded nanodroplets can non-invasively reduce blood pressure in a rat model of hypertension

Brain Stimulation (2024)

A minimally invasive neuromodulation technique was developed using focused ultrasound and anesthetic-loaded ultrasound nanodroplets for sustained treatment of hypertension. Scientists used the FUS Instruments RK-50 system for repeated sonications for sustained reduction in systolic and diastolic blood pressure up to 4 days.

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Ready to push the boundaries of what’s possible?

Our team of experts is ready to help you configure the perfect FUS setup for your specific research goals. Let’s build the future of non-invasive medicine together.