Programmable Hyperthermia & Ablation.
From controlled mild hyperthermia to high-intensity focal ablation, our systems provide precise thermal control. High-Intensity Focused Ultrasound (HIFU) can be used to induce rapid coagulative necrosis for the non-invasive destruction of solid tumors. Alternatively, our systems can maintain sustained, lower-level heating to enhance blood flow and trigger heat-sensitive drug release from liposomes, maximizing therapeutic concentration at the target site.
Whether investigating mild hyperthermia for drug release or high-intensity ablation, our systems deliver stable energy profiles tailored for small animal anatomy.
High-intensity FUS (HIFU) induces transgene lucerfin expression driven by heat shock protein HSP70 activation in engineered mesenchymal stem cells implanted in rat brain. HSP70 is activated at high temperatures induced by HIFU.
HIFU was delivered using MRI/MR-thermometry guided RK-100 (older version of RK-300)
Journal of Controlled Release 217 (2015): 113-120. [link to pub]
(Top) High-intensity focused ultrasound induces thermal injury and Schwann cell activation in the right sciatic nerve, as seen by increased p75 and cJun expression distal to the sonication site (arrow)
(Bottom) FUS-induced (using RK-50) predegenerated nerve graft in recipient rats showed increased soleus muscle weight compared to fresh nerve graft.
Scientific Reports 15.1 (2025): 15581
